Vaginal lipidomics of women with vulvovaginal candidiasis and cytolytic vaginosis: A non-targeted LC-MS pilot study.

José Marcos SanchesPaulo César GiraldoRose AmaralMarcos Nogueira EberlinLygia Azevedo MarquesIsabel MiglioriniMarcel NakahiraMichel Jan Marinus BieleveldMichelle Garcia Discacciati

Published in: PloS one (2018)

Lipids related to oxidative stress and apoptosis were found in higher concentrations in women with vulvovaginal candidiasis and cytolytic vaginosis, while lipids related to epithelial tissue integrity were more pronounced in the control group. Furthermore, in women with cytolytic vaginosis, we observed higher concentrations of lipids related to bacterial overgrowth.

Keyphrases

oxidative stress
candida albicans
fatty acid
dna damage
cell death
endoplasmic reticulum stress
ischemia reperfusion injury
drug induced
heat shock
heat stress