Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation.
Barry O'BrienJohn ReillyKen CoffeyAna Gonzalez-SuarezLeo QuinlanMartin van ZylPublished in: Journal of cardiovascular development and disease (2023)
Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people worldwide. The cardiac autonomic nervous system (ANS) is widely recognized as playing a key role in both the initiation and propagation of AF. This paper reviews the background and development of a unique cardioneuroablation technique for the modulation of the cardiac ANS as a potential treatment for AF. The treatment uses pulsed electric field energy to selectively electroporate ANS structures on the epicardial surface of the heart. Insights from in vitro studies and electric field models are presented as well as data from both pre-clinical and early clinical studies.
Keyphrases
- atrial fibrillation
- catheter ablation
- heart failure
- left ventricular
- left atrial
- machine learning
- left atrial appendage
- randomized controlled trial
- direct oral anticoagulants
- deep learning
- electronic health record
- venous thromboembolism
- risk assessment
- big data
- mitral valve
- artificial intelligence
- human health
- coronary artery disease
- replacement therapy
- case control