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Docosahexaenoic acid insufficiency impairs placental angiogenesis by repressing the methylene-bridge fatty acylation of AKT in preeclampsia.

Lidong LiuHuanqiang ZhaoYinan WangYutong CuiHuiqing LuYu XiongXirong XiaoQiongjie ZhouYiyuan YuanShimin ZhaoXiaotian Li
Published in: Placenta (2024)
Our results suggest that placental DHA insufficiency downregulates placental angiogenesis via inhibiting fatty acylating AKT and AKT-VEGFA signalling, a novel insight into abnormal fatty acid metabolism in PE.
Keyphrases
  • fatty acid
  • signaling pathway
  • cell proliferation
  • endothelial cells
  • vascular endothelial growth factor
  • early onset
  • wound healing
  • pregnant women
  • pregnancy outcomes