Naloxegol to Prevent Constipation in ICU Adults Receiving Opioids: A Randomized Double-Blind Placebo-Controlled Pilot Trial.

Matthew S DupreyHarmony AllisonErik GarpestadAndrew M RiselliAnthony FaugnoEric AnketellJohn W Devlin

Published in: Critical care research and practice (2022)

Important recruitment challenges exist for ICU trials evaluating the use of PAMORAs for constipation prevention. Despite being underpowered, our results suggest time to first SBM with naloxegol, if different than P, may be small. The effect of naloxegol on abdominal pressure, SOFA, and the interaction between the two requires further research.

Keyphrases

placebo controlled
double blind
intensive care unit
irritable bowel syndrome
mechanical ventilation
clinical trial
phase iii
phase ii
study protocol
chronic pain
phase ii study
pain management
randomized controlled trial
squamous cell carcinoma
radiation therapy
acute respiratory distress syndrome
rectal cancer