Rhesus macaques develop amyloid-β (Aβ) plaques during old age, but it is unclear how extensively they express other pathological hallmarks of dementia. Here we used immunohistochemistry to examine expression of phosphorylated tau (pTau) protein and cytoplasmic inclusions of TAR DNA binding protein 43 kDa (TDP-43) within the amygdala of young and old males, and also in old surgically-menopausal females that were maintained on regular or obesogenic diets. Only one animal, a 23-year-old female, showed pTau expression and none showed TDP-43 inclusions. What genetic and/or environmental factors protect macaques from expressing more severe human neuro-pathologies remains an interesting unresolved question.
Keyphrases
- binding protein
- poor prognosis
- mild cognitive impairment
- functional connectivity
- endothelial cells
- cognitive impairment
- cognitive decline
- amyotrophic lateral sclerosis
- resting state
- multidrug resistant
- early onset
- prefrontal cortex
- genome wide
- weight loss
- long non coding rna
- gene expression
- stress induced
- heat shock protein
- copy number
- protein protein