Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid-an Experimental Study.
Andreas SynetosKonstantinos ToutouzasMaria DrakopoulouIosif KoutagiarGeorge BenetosRafail KotroniasNikolaos Anousakis-VlachochristouGeorge LatsiosAntonis KaranasosGeorge AgrogiannisMarinos MetaxasKonstantinos StathogiannisAggelos PapanikolaouAlexandros GeorgakopoulosNikoleta PianouEleftherios TsiamisEfstratios PatsourisApostolos PapaloisDennis CokkinosConstantinos AnagnostopoulosDimitrios TousoulisPublished in: Journal of cardiovascular translational research (2018)
The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective.
Keyphrases
- aortic valve
- pet ct
- chronic kidney disease
- transcatheter aortic valve replacement
- aortic valve replacement
- transcatheter aortic valve implantation
- aortic stenosis
- randomized controlled trial
- positron emission tomography
- pulmonary artery
- systematic review
- physical activity
- clinical trial
- coronary artery disease
- pulmonary arterial hypertension
- coronary artery
- newly diagnosed