Effect of different corticosteroid regimes for hospitalised patients with exacerbated COPD: pooled analysis of individual participant data from the REDUCE and CORTICO-COP trials.
Pradeesh SivapalanJonas RutishauserCharlotte Suppli UlrikJörg D LeuppiLars PedersenBeat MuellerJosefin EklöfTor Biering-SørensenVibeke GottliebKarin ArmbrusterJulie JannerMia MobergTherese S LapperreThyge L NielsenAndrea BrowatzkiAlexander MathioudakisJørgen VestboPhilipp SchüetzJens-Ulrik JensenPublished in: Respiratory research (2021)
14-day corticosteroid regimens were associated with longer hospital stays and fewer days alive and out of hospital within 14 days, with no apparent 6-month benefit regarding death or admission to ICU in COPD patients. Our results favour 2-5 day regimens for treating COPD exacerbations. However, prospective studies are needed to validate these findings.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- end stage renal disease
- healthcare
- ejection fraction
- newly diagnosed
- emergency department
- chronic kidney disease
- intensive care unit
- acute care
- peritoneal dialysis
- randomized controlled trial
- prognostic factors
- adverse drug
- magnetic resonance imaging
- computed tomography
- magnetic resonance
- drug induced
- open label
- community acquired pneumonia
- study protocol