Low-dose Oral Thimerosal for the Treatment of Oral Herpes: Clinical Trial Results and Improved Outcome After Post-hoc Analysis.

Stephen W MamberThomas HatchCraig S MillerJohn V MurrayCynthia StroutJohn McMichael

Published in: Journal of evidence-based integrative medicine (2022)

Neither clinical trial showed a statistically significant effect of BTL-TML on progression to lesion. However, the post-hoc analysis suggested there is a 48-hour period following UV radiation exposure during which the anti-herpes activity of antivirals such as BTL-TML is reduced. Accordingly, BTL-TML may have promise in subsequent, properly designed and powered clinical trials.

Keyphrases

clinical trial
low dose
phase ii
open label
double blind
blood pressure
study protocol
phase iii
high dose
randomized controlled trial
big data
herpes simplex virus
machine learning
smoking cessation
aqueous solution