Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition.
Forrest L BakerKyle A SmithPreteesh L MylabathulaTiffany M ZúñigaDouglass M DiakHelena Angelica Pereira BatatinhaGrace M NiemiroMichael David SeckelerCharles R PedlarDaniel P O'ConnorJamie N ColomboEmmanuel KatsanisRichard J SimpsonPublished in: Cancer research communications (2024)
Exercise mobilizes effector γδ T-cells to blood via β2-adrenergic signaling which allows for generation of a potent expanded γδ T-cell product that is highly cytotoxic against hematologic malignancies.