Jaw Bone Invasion of Oral Squamous Cell Carcinoma Is Associated with Osteoclast Count and Expression of Its Regulating Proteins in Patients and Organoids.
Willem W B de KortWisse E HaakmaRobert J J van EsDebby GawlittaElse DriehuisMerel GansevoortStefan M WillemsPublished in: Journal of clinical medicine (2023)
These findings suggest that OSCCs induce bone invasion by stimulating osteoclast activation by regulating the production of RANKL and RANK proteins.