Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses.
Lovro ŽibernaZala Jenko-PražnikarAna PetelinPublished in: Antioxidants (Basel, Switzerland) (2021)
Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay between obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.
Keyphrases
- anti inflammatory
- oxidative stress
- weight loss
- obese patients
- low grade
- adipose tissue
- bariatric surgery
- insulin resistance
- metabolic syndrome
- roux en y gastric bypass
- type diabetes
- gastric bypass
- weight gain
- high grade
- dna damage
- high fat diet
- high fat diet induced
- induced apoptosis
- atrial fibrillation
- risk assessment
- ischemia reperfusion injury
- physical activity
- human health
- climate change
- skeletal muscle