Proton pump inhibitors and dementia risk: Evidence from a cohort study using linked routinely collected national health data in Wales, UK.
Roxanne CookseyJonathan KennedyMichael S DennisValentina Escott-PriceRonan A LyonsMichael J SeaborneSinead BrophyPublished in: PloS one (2020)
This study, using large-scale, multi-centre health-data was unable to confirm an association between PPI use and increased dementia risk. Previously reported links may be associated with confounders of people using PPI's, such as increased risk of cardiovascular disease and/or depression and their associated medications which may be responsible for any increased risk of developing dementia.
Keyphrases
- mild cognitive impairment
- cardiovascular disease
- cognitive impairment
- electronic health record
- healthcare
- big data
- public health
- protein protein
- depressive symptoms
- mental health
- metabolic syndrome
- cross sectional
- data analysis
- risk assessment
- coronary artery disease
- artificial intelligence
- cardiovascular events
- climate change
- deep learning