Prognosis research ideally should measure time-varying predictors at their intended moment of use.

Rebecca WhittleKara-Louise RoyleKelvin P JordanRichard D RileyChristian D MallenGeorge Peat

Published in: Diagnostic and prognostic research (2017)

The protocol for the PROG-RES cohort data collection and primary analysis has been published in an open-access journal (Mallen et al., BMC Musculoskelet Disord 7:84, 2006). The POST trial was registered (ISRCTN40721988; date of registration: 21 June 2011; date of enrolment of the first participant: 3 October 2011) and had a pre-specified protocol covering primary analysis. There was no published protocol for the current secondary analyses presented in this manuscript.

Keyphrases

randomized controlled trial
clinical trial
study protocol
machine learning
big data
meta analyses
open label
deep learning
artificial intelligence