Versatile Nickel(II) Scaffolds as Coordination-Induced Spin-State Switches for 19 F Magnetic Resonance-Based Detection.
Da XieMeng YuZhu-Lin XieRahul T KadakiaChris ChungLauren E OhmanKamyab JavanmardiEmily L QuePublished in: Angewandte Chemie (International ed. in English) (2020)
19 F magnetic resonance (MR) based detection coupled with well-designed inorganic systems shows promise in biological investigations. Two proof-of-concept inorganic probes that exploit a novel mechanism for 19 F MR sensing based on converting from low-spin (S=0) to high-spin (S=1) Ni2+ are reported. Activation of diamagnetic NiL1 and NiL2 by light or β-galactosidase, respectively, converts them into paramagnetic NiL0 , which displays a single 19 F NMR peak shifted by >35 ppm with accelerated relaxation rates. This spin-state switch is effective for sensing light or enzyme expression in live cells using 19 F MR spectroscopy and imaging that differentiate signals based on chemical shift and relaxation times. This general inorganic scaffold has potential for developing agents that can sense analytes ranging from ions to enzymes, opening up diverse possibilities for 19 F MR based biosensing.
Keyphrases
- magnetic resonance
- single molecule
- contrast enhanced
- room temperature
- density functional theory
- high resolution
- transition metal
- label free
- living cells
- water soluble
- poor prognosis
- magnetic resonance imaging
- loop mediated isothermal amplification
- tissue engineering
- small molecule
- computed tomography
- quantum dots
- fluorescence imaging
- real time pcr
- oxidative stress
- binding protein
- mass spectrometry
- perovskite solar cells
- artificial intelligence
- big data
- climate change
- aqueous solution
- reduced graphene oxide
- long non coding rna