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Safety and efficacy of intravenous thrombolysis in stroke patients on prior antiplatelet therapy in the WAKE-UP trial.

Benedikt M FreyFlorent BoutitieBastian ChengTae-Hee ChoMartin EbingerMatthias EndresJochen B FiebachJens FiehlerIan FordIvana GalinovicAlina KönigsbergJosep PuigPascal RoyAnke WoutersTim MagnusVincent ThijsRobin LemmensKeith W MuirNorbert NighoghossianSalvador PedrazaClaus Z SimonsenChristian GerloffGötz Thomallanull null
Published in: Neurological research and practice (2020)
Treatment benefit of intravenous alteplase and rates of post-treatment hemorrhagic transformation were not modified by prior antiplatelet intake among MRI-selected patients with unknown onset stroke. Worse functional outcome in patients on antiplatelets may result from a higher load of cardiovascular co-morbidities in these patients.
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