Relationships between longitudinal neutrophil to lymphocyte ratios, body weight changes, and overall survival in patients with non-small cell lung cancer.
Benjamin A DermanJ N MacklisM S AzeemS SayidineS BasuM BatusF EsmailJ A BorgiaP BonomiM J FidlerPublished in: BMC cancer (2017)
High baseline and progressive increases in NLRs are associated with progressive disease, inferior OS and weight loss in NSCLC patients. In addition to having prognostic significance, these observations suggest that studying molecular mediators of cachexia/inflammation and their relationships to tumor progression may identify new therapeutic targets in the large subset of NSCLC patients who have cancer cachexia.
Keyphrases
- end stage renal disease
- small cell lung cancer
- newly diagnosed
- body weight
- ejection fraction
- weight loss
- chronic kidney disease
- peritoneal dialysis
- multiple sclerosis
- prognostic factors
- oxidative stress
- type diabetes
- poor prognosis
- advanced non small cell lung cancer
- long non coding rna
- body mass index
- obese patients