A safety and feasibility trial of 131 I-MIBG in newly diagnosed high-risk neuroblastoma: A Children's Oncology Group study.

Brian D WeissGregory YanikArlene NaranjoFan F ZhangWendy FitzgeraldBarry L ShulkinMarguerite T ParisiHeidi V RussellStephan GruppLuke PaterPeter MatteiYael MosseHollie A LaiJason A JarzembowskiHiroyuki ShimadaJudith G VillablancaRoger GillerRochelle BagatellJulie R ParkKatherine K Matthay

Published in: Pediatric blood & cancer (2021)

This pilot trial demonstrated feasibility and tolerability of administering 131 I-MIBG followed by myeloablative therapy with Bu/Mel to newly diagnosed children with high-risk neuroblastoma in a cooperative group setting, laying the groundwork for a cooperative randomized trial (NCT03126916) testing the addition of 131 I-MIBG during induction therapy.

Keyphrases

newly diagnosed
young adults
clinical trial
palliative care
study protocol
open label
phase iii
randomized controlled trial
heat stress
low dose
mesenchymal stem cells
acute myeloid leukemia
cell therapy