Login / Signup

Mediation of Interleukin-23 and Tumor Necrosis Factor-Driven Reactive Arthritis by Chlamydia-Infected Macrophages in SKG Mice.

Xavier RomandXiao LiuM Arifur RahmanZaied Ahmed BhuyanClaire DouillardReena Arora KediaNathan StoneDominique RoestZi Huai ChewAmy J CameronLinda M RehaumeAurélie BozonMohammed HabibCharles W ArmitageMinh Vu Chuong NguyenBertrand FavierKenneth BeagleyMax MaurinPhilippe GaudinRanjeny ThomasTimothy J WellsAthan Baillet
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
C muridarum load is higher in SKG mice than in BALB/c mice. Whereas proinflammatory IL-23 produced by neutrophils contributes to the initiation of C muridarum-mediated ReA, macrophage depletion reduces C muridarum dissemination to other tissues, tissue burden, and the development of arthritis. TNF inhibition was also shown to suppress arthritis development. Our data suggest that enhanced bacterial dissemination in macrophages of SKG mice drives the TNF production needed for persistent arthritis.
Keyphrases
  • rheumatoid arthritis
  • high fat diet induced
  • gene expression
  • adipose tissue
  • type diabetes
  • insulin resistance
  • machine learning
  • social support
  • deep learning
  • skeletal muscle