Potential genetic markers for nonsyndromic oral clefts in the Brazilian population: A systematic review and meta-analysis.

Renato Assis MachadoIsabela Porto de ToledoHercilio Martelli-JúniorSilvia Regina ReisEliete Neves Silva GuerraRicardo Della Coletta

Published in: Birth defects research (2018)

A large number of genetic markers distributed in several genes/loci was associated with NOC in the Brazilian population, but in general the original studies included limited number of samples and unsatisfactory protocols. The classical risk markers located in IRF6 and 8q24 showed promising results as well as rs1801133 in MTHFR and rs17563 in BMP4, and they should be validated in larger and multicenter studies taking in consideration the variations in the miscegenation of Brazilian population.

Keyphrases

genome wide
dna methylation
mesenchymal stem cells
case control
dendritic cells
cross sectional
double blind