In vivo safety and biodistribution profile of Klotho-enhanced human urine-derived stem cells for clinical application.

Sang-Heon KimSung-Hoon LeeJeong-Ah JinHyung-Joon SoJae-Ung LeeMin-Jae JiEun-Joong KwonPyo-Sung HanHong-Ki LeeTae-Wook Kang

Published in: Stem cell research & therapy (2023)

Our results demonstrate that Klotho-enhanced UDSCs can be manufactured as cell therapeutics through an optimized GMP procedure, and they can be safely administered without causing toxicity and tumorigenicity.

Keyphrases

stem cells
endothelial cells
cell therapy
single cell
small molecule
induced pluripotent stem cells
biofilm formation
pluripotent stem cells
pet imaging
escherichia coli
pseudomonas aeruginosa
cystic fibrosis
bone marrow