Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS.
Marcelo L M PereiraLuana S OrtolanMichelle K SercundesDaniela DeboneOscar MurilloFlávia A LimaClaudio Romero Farias MarinhoSabrina EpiphanioPublished in: Mediators of inflammation (2016)
Malaria is a serious disease, caused by the parasite of the genus Plasmodium, which was responsible for 440,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications in severe malaria. The murine model DBA/2 reproduces the clinical signs of ALI/ARDS in humans, when infected with Plasmodium berghei ANKA. High levels of HO-1 were reported in cases of severe malaria. Our data indicated that the HO-1 mRNA and protein expression are increased in mice that develop malaria-associated ALI/ARDS (MA-ALI/ARDS). Additionally, the hemin, a HO-1 inducing drug, prevented mice from developing MA-ALI/ARDS when administered prior to the development of MA-ALI/ARDS in this model. Also, hemin treatment showed an amelioration of respiratory parameters in mice, high VEGF levels in the sera, and a decrease in vascular permeability in the lung, which are signs of ALI/ARDS. Therefore, the induction of HO-1 before the development of MA-ALI/ARDS could be protective. However, the increased expression of HO-1 on the onset of MA-ALI/ARDS development may represent an effort to revert the phenotype of this syndrome by the host. We therefore confirm that HO-1 inducing drugs could be used for prevention of MA-ALI/ARDS in humans.
Keyphrases
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation
- plasmodium falciparum
- emergency department
- intensive care unit
- metabolic syndrome
- lipopolysaccharide induced
- endothelial cells
- type diabetes
- poor prognosis
- machine learning
- deep learning
- long non coding rna
- electronic health record
- cell proliferation
- drug induced
- skeletal muscle
- signaling pathway