Safety and efficacy of cefiderocol for off-label treatment indications: A systematic review.

Riyan BabidhanAbigale LewisCailin AtkinsNicolas J JozefczykBranden D NemecekCourtney A Montepara Michael R GionfriddoDavid E ZimmermanJordan R Covvey Anthony J Guarascio

Published in: Pharmacotherapy (2022)

This systematic review depicts relative clinical effectiveness of off-label cefiderocol, most commonly for P. aeruginosa and A. baumannii infections as combination antibiotic therapy. Further study is needed to elucidate the safety and efficacy of cefiderocol across an expanded set of patients and indications.

Keyphrases

systematic review
gram negative
end stage renal disease
newly diagnosed
ejection fraction
randomized controlled trial
prognostic factors
meta analyses
multidrug resistant
peritoneal dialysis
stem cells
replacement therapy