L1CAM overexpression promotes tumor progression through recruitment of regulatory T cells in esophageal carcinoma.

Xuan ZhaoShasha LiuXinfeng ChenJianyi ZhaoFeng LiQitai ZhaoTan XieLan HuangZhen ZhangYu QiYang YangSong ZhaoYi Zhang

Published in: Cancer biology & medicine (2021)

Our findings provide new insight into the mechanism of immune evasion mediated by L1CAM, suggesting that targeting L1CAM-CCL22-TGF-β crosstalk between tumor cells and Tregs may offer a unique means to improve treatment of patients with ESCC.

Keyphrases

regulatory t cells
dendritic cells
poor prognosis
cell proliferation
transcription factor
transforming growth factor
cancer therapy
liver fibrosis
liver injury
replacement therapy