Diagnostic yield and clinical relevance of expanded genetic testing for cancer patients.

Ozge Ceyhan-BirsoyGowtham JayakumaranYelena KemelMaksym MisyuraUmut AyparSowmya JairamCiyu YangYirong LiNikita MehtaAnna MaioAngela ArnoldErin Salo-MullenMargaret SheehanAijazuddin SyedMichael WalshMaria CarloMark RobsonKenneth OffitMarc LadanyiJorge S Reis-FilhoZsofia K StadlerLiying ZhangAlicia LathamAhmet ZehirDiana L Mandelker

Published in: Genome medicine (2022)

Compared to targeted testing approaches, eGT can increase the yield of detection of hereditary cancer predisposition in patients with a range of tumors, allowing opportunities for enhanced surveillance and intervention. The benefits of performing eGT should be weighed against the added number of VUSs identified with this approach.

Keyphrases

papillary thyroid
randomized controlled trial
public health
squamous cell
loop mediated isothermal amplification
cancer therapy
real time pcr
quantum dots
sensitive detection