PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis.
Elena MeuserKyle ChangAngharad WaltersJoanna J HurleyHannah D WestIain PerryMatthew MortLaura Reyes-UribeRebekah TruscottNicholas JonesRachel LawrenceGareth J S JenkinsPeter J GilesSunil DolwaniBilal Al-SarirehNeil HawkesEmma L ShortGeraint T WilliamsMelissa W TaggartKim LuetchfordPatrick M LynchDiantha TerlouwMaartje NielsenSarah-Jane WaltonAndrew LatchfordSusan K ClarkJulian R SampsonEduardo VilarLaura E ThomasPublished in: Molecular cancer research : MCR (2024)
PIGA somatic mutation in duodenal tumors from patients with FAP and MAP and loss of membrane GPI-anchors may present new opportunities for understanding and intervention in duodenal tumorigenesis.