The effect of substance P and its specific antagonist (aprepitant) on the expression of MMP-2, MMP-9, VEGF, and VEGFR in ovarian cancer cells.

Maryam Momen RazmgahAtefeh GhahremanlooHossein JavidAbbas AlAlikhanAmir-R AfshariSeyed Isaac Hashemy

Published in: Molecular biology reports (2022)

Overall, the SP/NK1R system plays a vital role in ovarian cancer progression, and the inhibition of NK1Rusing aprepitant could inhibit the spread of ovarian cancer cells through metastasis and angiogenesis.

Keyphrases

vascular endothelial growth factor
endothelial cells
nk cells
poor prognosis
chemotherapy induced
cell migration
wound healing