TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function.
Grégory MerlenNicolas KahaleJose Ursic-BedoyaValeska Bidault-JourdainneHayat SimerabetIsabelle DoignonZahra TanfinIsabelle GarcinNoémie PéanJulien GautherotAnne Davit-SpraulCatherine GuettierLydie HumbertDominique RainteauKlaus EbnetChristoph UllmerDoris CassioThierry TordjmannPublished in: Gut (2019)
The BA receptor TGR5 regulates biliary epithelial barrier function in vitro and in vivo through an impact on JAM-A expression and phosphorylation, thereby protecting liver parenchyma against bile leakage.