Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of Nucleophosmin in human cardiac mesenchymal progenitor cells.
Sara BejiMarco D'AgostinoElisa GambiniSara SilenoAlessandro ScopeceMaria Cristina VinciGiuseppina MilanoGuido MelilloMonica NapolitanoGiulio PompilioMaurizio C CapogrossiDaniele AvitabileAlessandra MagentaPublished in: BMC biology (2021)
We hypothesise that the extracellular release of NPM could be a general response to DNA damage since it can be elicited by either a chemical agent such as Dox or a physical genotoxic stressor such as UV radiation. Following genotoxic stress, NPM acts similarly to an alarmin in hCmPCs, being rapidly secreted and promoting cell cycle arrest and a TLR4/NFκB-dependent inflammatory response.
Keyphrases
- inflammatory response
- lps induced
- cell cycle arrest
- dna damage
- acute myeloid leukemia
- toll like receptor
- pi k akt
- lipopolysaccharide induced
- cell death
- nuclear factor
- oxidative stress
- endothelial cells
- signaling pathway
- immune response
- stem cells
- mental health
- physical activity
- bone marrow
- left ventricular
- dna repair
- cell proliferation
- pluripotent stem cells
- radiation induced
- radiation therapy