Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2.

Fang-Ling ZhangXiao-Wei ChenYi-Fan WangZhen HuWen-Juan ZhangBo-Wei ZhouPeng-Fei CiWei-Feng Liu

Published in: Journal of translational medicine (2023)

The content of tryptophan metabolite ILA in the preoperative feces of patients is negatively correlated with intestinal function damage under CPB surgery. Administration of ILA alleviates intestinal I/R injury via the regulation of YAP and Nrf2. This study revealed a novel therapeutic metabolite and promising candidate targets for intestinal I/R injury treatment.

Keyphrases

oxidative stress
ischemia reperfusion injury
end stage renal disease
lactic acid
chronic kidney disease
ejection fraction
patients undergoing
prognostic factors
mouse model
coronary artery bypass
ms ms
coronary artery disease
combination therapy