Hypoxia-Inducible Factor 1 Alpha-Mediated RelB/APOBEC3B Down-regulation Allows Hepatitis B Virus Persistence.
Tobias RiedlSuzanne Faure-DupuyMaude RollandSvenja SchuehleZohier HizirSilvia CalderazzoXiaodong ZhuangJochen WettengelMartin Alexander LopezRomain BarnaultValbona MirakajSandra ProkoschDanijela HeideCorinna LeuchtenbergerMartin SchneiderBernd HeßlingBenjamin StottmeierIsabel Madeleine KleinPeter SchirmacherJane A McKeatingUlrike ProtzerDavid DurantelJulie LuciforaEmmanuel DejardinMathias F HeikenwälderPublished in: Hepatology (Baltimore, Md.) (2021)
In conclusion, inhibiting HIF1α expression or stabilization represents an anti-HBV strategy in the context of immune-mediated A3B induction. High HIF1α, mediated by hypoxia or inflammation, offers a reservoir for HBV survival in vivo and should be considered as a restricting factor in the development of immune therapies.