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Hypoxia-Inducible Factor 1 Alpha-Mediated RelB/APOBEC3B Down-regulation Allows Hepatitis B Virus Persistence.

Tobias RiedlSuzanne Faure-DupuyMaude RollandSvenja SchuehleZohier HizirSilvia CalderazzoXiaodong ZhuangJochen WettengelMartin Alexander LopezRomain BarnaultValbona MirakajSandra ProkoschDanijela HeideCorinna LeuchtenbergerMartin SchneiderBernd HeßlingBenjamin StottmeierIsabel Madeleine KleinPeter SchirmacherJane A McKeatingUlrike ProtzerDavid DurantelJulie LuciforaEmmanuel DejardinMathias F Heikenwälder
Published in: Hepatology (Baltimore, Md.) (2021)
In conclusion, inhibiting HIF1α expression or stabilization represents an anti-HBV strategy in the context of immune-mediated A3B induction. High HIF1α, mediated by hypoxia or inflammation, offers a reservoir for HBV survival in vivo and should be considered as a restricting factor in the development of immune therapies.
Keyphrases
  • hepatitis b virus
  • liver failure
  • endothelial cells
  • poor prognosis
  • oxidative stress
  • signaling pathway