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Molecular determinants of neutrophil extracellular vesicles that drive cartilage regeneration in inflammatory arthritis.

Bethan L ThomasTrinidad Montero-MelendezSilvia OggeroMagdalena K KanevaDavid ChambersAndreia L PintoAlessandra NervianiDavide LucchesiShani Austin-WilliamsMohammed T HussainCostantino PitzalisBenjamin AllenMarzia MalcangioFrancesco Dell'AccioLucy Victoria NorlingMauro Perretti
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Neutrophils from RA patients yielded EVs with composition, efficacy and miR-455-3p content similar to those of healthy volunteers, suggesting that neutrophil EVs could be developed as an autologous treatment to protect and repair joint tissue of patients affected by inflammatory arthritides.
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