Molecular determinants of neutrophil extracellular vesicles that drive cartilage regeneration in inflammatory arthritis.
Bethan L ThomasTrinidad Montero-MelendezSilvia OggeroMagdalena K KanevaDavid ChambersAndreia L PintoAlessandra NervianiDavide LucchesiShani Austin-WilliamsMohammed T HussainCostantino PitzalisBenjamin AllenMarzia MalcangioFrancesco Dell'AccioLucy Victoria NorlingMauro PerrettiPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Neutrophils from RA patients yielded EVs with composition, efficacy and miR-455-3p content similar to those of healthy volunteers, suggesting that neutrophil EVs could be developed as an autologous treatment to protect and repair joint tissue of patients affected by inflammatory arthritides.