The impact of short-chain fatty acid-producing bacteria of the gut microbiota in hyperuricemia and gout diagnosis.
Gabriela A Martínez-NavaEder O Méndez-SalazarJanitzia Vázquez-MelladoYessica Zamudio-CuevasAdriana Francisco-BalderasKarina Martínez-FloresJavier Fernández-TorresCarlos Lozada-PérezDafne L Guido-GómoraLaura E Martínez-GómezGuadalupe E Jiménez-GutiérrezCarlos PinedaLuis H SilveiraLaura Sánchez-ChapulRoberto Sánchez-SánchezMaría Del Carmen Camacho-ReaCarlos Martínez-ArmentaAna I Burguete-GarcíaCitlalli Orbe-OrihuelaAlfredo Lagunas-MartínezBerenice Palacios-GonzálezAlberto Gabriel López-ReyesPublished in: Clinical rheumatology (2022)
We observed a distinctive taxonomic profile in AH individuals characterized by a higher abundance of short-chain fatty acid-producing bacteria in comparison to those observed in gout patients. Furthermore, we provide scientific evidence that indicates that the gut microbiota of AH individuals could provide anti-inflammatory mediators, which prevent the appearance of gout flares. Key Points • AH and gout patients both have a higher abundance of Prevotella genus bacteria than controls. • AH individuals' gut microbiota had more butyrate- and propionate-producing bacteria than gout patients. • The gut microbiome of AH individuals provides anti-inflammatory mediators that could prevent gout flares.