Comparison of the Effectiveness and Safety of Clozapine Between Once-Daily and Divided Dosing Regimen in Patients With Treatment-Resistant Schizophrenia.
Thanompong SathienluckanaThaksin JansingSupakan SrisuriyakamonAunchalee ThonkhunthodParsiri SangsuwantoPholphat LosatiankijSuttha SupanyaPublished in: The Annals of pharmacotherapy (2023)
In patients with treatment-resistant schizophrenia, there were no significant differences in effectiveness or safety between once-daily and divided dosing of clozapine. Further prospective studies with larger sample sizes are required to confirm these findings.