Gene co-expression and histone modification signatures are associated with melanoma progression, epithelial-to-mesenchymal transition, and metastasis.

Hátylas AzevedoGuilherme Cavalcante PessoaFrancisca Nathália de Luna VitorinoJérémie NsengimanaJulia Newton-BishopEduardo Moraes ReisJúlia Pinheiro Chagas da CunhaMiriam Galvonas Jasiulionis

Published in: Clinical epigenetics (2020)

We uncovered transcriptional and histone modification signatures that may be molecular events driving melanoma progression and metastasis, which can aid in the identification of novel prognostic genes and drug targets for treating the disease.

Keyphrases

genome wide
dna methylation
gene expression
bioinformatics analysis
poor prognosis
copy number
genome wide identification
skin cancer
transcription factor
basal cell carcinoma
emergency department
genome wide analysis
binding protein
oxidative stress