Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer.

Alexandra GiatromanolakiAchilleas G Mitrakas Ioannis AnestopoulosAndreas KontosisIoannis M KoukourakisAglaia Pappa Mihalis I PanayiotidisMichael I Koukourakis

Published in: Cancers (2022)

TAMs play an important role in the prognosis of operable NSCLC. As SIRPα+ macrophages adversely affect prognosis, it is suggested that the CD47/SIRPα axis is a sound target for adjuvant immunotherapy policies, aiming to improve the cure rates in operable NSCLC.

Keyphrases

small cell lung cancer
advanced non small cell lung cancer
poor prognosis
early stage
public health
nk cells
adipose tissue
binding protein
tyrosine kinase