Association of Genetic Alterations with Prognosis in Extramammary Paget's Disease: Insights into the Involvement of somatic CDKN2A variants in Poor Prognosis.
Okuto IwasawaMasachika IkegamiTakuya MiyagawaHiromichi MoritaHinako SaitoIssei OmoriKentaro AwajiJun OmatsuDaisuke YamadaHidenori KageKatsutoshi OdaShinichi SatoHayakazu SumidaPublished in: The British journal of dermatology (2024)
Somatic CDKN2A variant, mainly exhibiting loss, may be associated with poor prognosis in EMPD. Cases with BRCA2-mutant cancer might also have a worse prognosis in EMPD. In addition, CGP testing before PS deteriorates is preferable, considering the observed median survival of individuals undergoing CGP tests in an ECOG-PS-1 condition was less than 9 months.