Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stage.
Jelle VlaanderenMax LeendersMarc Chadeau-HyamLützen PortengenSoterios A KyrtopoulosIngvar A BergdahlAnn-Sofie JohanssonDennie D G A J HebelsTheo M C M de KokPaolo VineisRoel C H VermeulenPublished in: BMC genomics (2017)
An overlap exists between expression levels of genes predictive of CLL identified in prediagnostic blood and expression levels of genes associated to CLL at the clinical stage. Our analysis provides insight in a set of genes for which expression levels can be used to follow the time-course of the disease; providing an opportunity to study CLL progression in more detail in future studies.