Beneficial effects of atorvastatin on sex-specific cognitive impairment induced by a cerebral microhaemorrhage in mice.

Sandrine Bergeron Romain BarusClémence LeboullengerFlorent AugerAntonino BongiovanniMeryem TardivelAurélie JonneauxCharlotte LalouxCamille PoteyRégis BordetYaohua ChenSophie Gautier

Published in: British journal of pharmacology (2021)

Atorvastatin modulated the sex-specific cognitive impairment induced by the CMH with a pathophysiological impact mainly within the cortical area. It could represent a promising candidate for future sex-stratified clinical trials in patients with CMH.

Keyphrases

cognitive impairment
clinical trial
subarachnoid hemorrhage
current status
high fat diet induced
randomized controlled trial
skeletal muscle
adipose tissue
brain injury
insulin resistance
phase iii
cerebral blood flow