FGF Ligands and Receptors in Osteochondral Tissues of the Temporomandibular Joint in Young and Aging Mice.

Eliane H DutraPo-Jung ChenZana KalajzicSunil WadhwaMarja HurleySumit Yadav

Published in: Cartilage (2023)

Our results indicate FGF2 and FGF8 are important growth factors for mandibular condylar cartilage growth in young mice but with limited role in the cartilage of older mice. In addition, the increased expression of pFGFR1 and FGF9 and the decreased expression of pFGFR3 and FGF18 as mice aged suggest the association of these factors with aging and osteoarthritis of the cartilage of the mandibular condyle.

Keyphrases

high fat diet induced
poor prognosis
type diabetes
metabolic syndrome
knee osteoarthritis