Systemic Alterations of Wnt Inhibitors in Patients with Prostate Cancer and Bone Metastases.

Stefan AufderklammJörg HennenlotterPhillip LeidenbergerSteffen RauschAndrea HohnederUrsula KühsMoritz MaasChristian SchwentnerJens BedkeArnulf StenzlTilman Todenhöfer
Published in: Disease markers (2018)
DKK-1 is involved in the progression of PC. DKK-1-mediated inhibition of osteoblasts, which contributes to tumor progression and osteolytic metastases, may also play a role in the development of metastases with osteoblastic features. The use of DKK-1 antibodies should be considered for studies including metastatic PC patients.