Novel Liver Injury Phenotypes and Outcomes in Clinical Trial Participants with Pulmonary Hypertension.
Jacqueline V ScottJude MoutchiaRobin L McClellandNadine Al-NaamaniEthan WeinbergHarold I PalevskyJasleen MinhasDina K ApplebyAkaya SmithSteven C PuglieseCorey E VentetuoloSteven M KawutPublished in: American journal of respiratory and critical care medicine (2024)
Liver injury was associated with adverse outcomes in patients with PAH and CTEPH. Randomization to active treatment had beneficial effects on liver health compared to placebo. The role of liver disease (often subclinical) in determining outcomes warrants prospective studies.