MTOR Suppresses Cigarette Smoke-Induced Airway Inflammation and MMP12 Expression in Macrophage in Chronic Obstructive Pulmonary Disease.
Lingling DongYong WangHaipin ChenZhou-Yang LiXuchen XuJiesen ZhouHuahao ShenZhi-Hua ChenPublished in: International journal of chronic obstructive pulmonary disease (2024)
Macrophage MTOR can reduce the expression of MMP12 by inhibiting NF-κB, thereby inhibiting the occurrence of COPD inflammation and destruction of lung tissue structure. Activating the activity of macrophage MTOR may be beneficial for the treatment of COPD.
Keyphrases
- signaling pathway
- poor prognosis
- chronic obstructive pulmonary disease
- adipose tissue
- cell proliferation
- oxidative stress
- pi k akt
- lung function
- risk assessment
- diabetic rats
- high glucose
- lps induced
- long non coding rna
- inflammatory response
- drug induced
- immune response
- nuclear factor
- endothelial cells
- toll like receptor