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Balancing key stakeholder priorities and ethical principles to design a trial comparing intervention or expectant management for early-onset selective fetal growth restriction in monochorionic twin pregnancy: FERN qualitative study.

Tracy Karen MitchellMariana PopaRichard Edmund AshcroftSmriti PrasadAndrew N SharpChristine CarnforthMark A TurnerAsma KhalilNatasha FenwickShauna Levennull nullKerry Woolfall
Published in: BMJ open (2024)
All three pregnancy management approaches for sFGR in MC twin pregnancy carry risks and benefits, and the ultimate goal for parents is to receive individualised care to achieve the best possible outcome for both twins. An RCT was not acceptable to parents or clinicians or seen as ethically appropriate. Alternative study designs should be considered to answer this important research question.
Keyphrases
  • early onset
  • preterm birth
  • pregnancy outcomes
  • late onset
  • palliative care
  • healthcare
  • randomized controlled trial
  • clinical trial
  • gestational age
  • pain management
  • phase iii