In Vitro Assessment of Antiplasmodial Activity and Cytotoxicity of Polyalthia longifolia Leaf Extracts on Plasmodium falciparum Strain NF54.

Bethel Kwansa-BentumKojo AgyemanJeffrey Larbi-AkorClaudia AnyigbaRegina Appiah-Opong

Published in: Malaria research and treatment (2019)

The extracts of P. longifolia have antiplasmodial properties and low toxicities to human red blood cells. The extracts could be developed as useful alternatives to antimalarial drugs. These results support claims of the herbalists that decoctions of P. longifolia are useful antimalarial agents.

Keyphrases

plasmodium falciparum
red blood cell
endothelial cells
signaling pathway
oxidative stress
lps induced
induced pluripotent stem cells
pluripotent stem cells
drug induced
clinical evaluation