Whole blood transfusion versus component therapy in trauma resuscitation: a systematic review and meta-analysis.
Ellen CroweStacia M DeSantisAustin BonnetteJan O JansenJose-Miguel YamalJohn B HolcombClaudia PedrozaJohn A HarvinMarisa B MarquesElenir B C AvritscherHenry E WangPublished in: Journal of the American College of Emergency Physicians open (2020)
In this systematic review and meta-analysis, compared with conventional component transfusion, whole blood was not associated with 24-hour or in-hospital mortality. However, there were important limitations with and heterogeneity among the primary studies. Additional study is needed to determine the effectiveness of whole blood.