Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease.

Chengjie XiongLena M McCueVirginia BucklesElizabeth GrantFolasade AgboolaDean CobleRandall J BatemanAnne M FaganTammie L S BenzingerJason HassenstabSuzanne E SchindlerEric McDadeKrista MoulderBrian A GordonCarlos CruchagaGregory S DayTakeshi IkeuchiKazushi SuzukiRicardo F AllegriJonathan VögleinJohannes LevinJohn C Morrisnull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Preclinical ADAD and LOAD share many biomarker signatures, but cross-sectional and longitudinal differences may exist.

Keyphrases

cross sectional
late onset
middle aged
early onset
mild cognitive impairment
genome wide
white matter
cell therapy
stem cells
gene expression
multiple sclerosis