A single locus determines praziquantel response in Schistosoma mansoni .

Frédéric D Chevalier Winka LE Clec'h Matthew Berriman Timothy J C Anderson

Published in: Antimicrobial agents and chemotherapy (2024)

We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci situated on chromosomes 2 and 3. We reanalyzed this GWAS using the latest (version 10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that PZQ response is monogenic and demonstrates the importance of high-quality genomic information.

Keyphrases

genome wide association study
genome wide
copy number
dna methylation
emergency department
gene expression
drug induced