Endoplasmic reticulum stress regulates mechanical stress-induced ossification of posterior longitudinal ligament.
Lei ShiJinhao MiaoDeyu ChenJiangang ShiYu ChenPublished in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2019)
Activated ER stress was observed in OPLL patients both in vitro and in vivo. Mechanical stress could activate ER stress response in posterior longitudinal ligament fibroblasts and further promote OPLL in vitro. In this process, ER stress might work through the MAPK signaling pathways. These slides can be retrieved under Electronic Supplementary Material.