Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications.
Katarzyna CzerwiecMałgorzata ZawrzykrajMilena DeptułaAneta SkonieckaAgata TymińskaJacek ZielińskiAdam KosińskiMichal PikulaPublished in: International journal of molecular sciences (2023)
Adipose-derived mesenchymal stromal cells (AD-MSCs) have been extensively studied in recent years. Their attractiveness is due to the ease of obtaining clinical material (fat tissue, lipoaspirate) and the relatively large number of AD-MSCs present in adipose tissue. In addition, AD-MSCs possess a high regenerative potential and immunomodulatory activities. Therefore, AD-MSCs have great potential in stem cell-based therapies in wound healing as well as in orthopedic, cardiovascular, or autoimmune diseases. There are many ongoing clinical trials on AD-MSC and in many cases their effectiveness has been proven. In this article, we present current knowledge about AD-MSCs based on our experience and other authors. We also demonstrate the application of AD-MSCs in selected pre-clinical models and clinical studies. Adipose-derived stromal cells can also be the pillar of the next generation of stem cells that will be chemically or genetically modified. Despite much research on these cells, there are still important and interesting areas to explore.
Keyphrases
- mesenchymal stem cells
- stem cells
- umbilical cord
- adipose tissue
- bone marrow
- clinical trial
- cell therapy
- wound healing
- systematic review
- randomized controlled trial
- healthcare
- induced apoptosis
- type diabetes
- metabolic syndrome
- climate change
- high fat diet
- cell death
- insulin resistance
- cell proliferation
- cell cycle arrest
- open label
- oxidative stress
- endoplasmic reticulum stress