Burden of systemic lupus erythematosus in clinical practice: baseline data from the SLE Prospective Observational Cohort Study (SPOCS) by interferon gene signature.
Laurent ArnaudRichard A FurieEric F MorandMartin AringerChristine PeschkenBarnabas DestaEleni RapsomanikiJonatan HedbergJacob KnagenhjelmCaroline SeoTina Grünfeld EénAlessandro SorrentinoRaj TummalaHeide A Stirnadel-FarrantBo DingPublished in: Lupus science & medicine (2023)
We identified key characteristics of patients with high disease activity and/or elevated type I IFN signalling, populations with SLE with high unmet needs. Baseline SLEDAI-2K ≥10 was associated with shorter disease duration and more severe flares. IFNGS-high patients were younger at diagnosis and had distinct patterns of organ involvement, compared with IFNGS-low patients.
Keyphrases
- systemic lupus erythematosus
- disease activity
- end stage renal disease
- rheumatoid arthritis
- newly diagnosed
- chronic kidney disease
- ejection fraction
- rheumatoid arthritis patients
- clinical practice
- peritoneal dialysis
- dendritic cells
- ankylosing spondylitis
- gene expression
- copy number
- dna methylation
- early onset
- machine learning
- juvenile idiopathic arthritis
- big data
- electronic health record
- artificial intelligence
- drug induced
- genetic diversity